Based on the field geologic investigation data, the seismic reflection features of target zones and tectonic deformation theory on orogeny, the structural interpretation model for Wuboer structural belt in southwestern Tarim Basin is developed. And this model is analyzed using software 2-D move for structural section balance and restoration. The generally balanced structural model reveals that with tectonic uplifting since Late Pliocene, the Cenozoic strata are subjected to denudation, indicating that in Cenozoic the strongest movement occurs in Late Pliocene.