The large-scale low-temperature metallogenic domain in the southwestern China is one of the two large-scale low-temperature metallogenic domains in the world. It is also an important production base of Au, Hg, Sb, As, P, Pb-Zn, U, Ag and dispersed elements in China. This paper not only synthetically analyzes the research history, the research content in different stages, the research achievements and the scientific problems, but also describes the new progresses on the large-scale low-temperature metallogenic domain in the southwestern China in recent years.