Dengfeng karst area is influenced by human mining activities and causes groundwater level fallen, part regional karst water-bearing stratum is destroyed, the surface is lack of water terribly and the hydrogeology condition is changed. Drought resistance in karst region of Dengfeng during March and April in 2011 is taken as an example, it analyzes the occurrence characteristics and regulation of karst water in this area, then the well spacing direction is carried out.