Hongyuan Pb-Zn-sulfide deposit in Hami of Xinjiang is located in the east of Central Tianshan Block, it was found in measuring Pb-Zn-Ag composite anomalies from 1:50 000 stream sediment in 2003. On the basis of the other’s hard work, summarized the geological and geochemical characteristics of the deposit and prospecting marks, and provided foundation and criteria on finding this type of deposit in the area.