Main working area of this paper is part of ocean from Qiongdongnan Basin to Xisha Trough in South China Sea. On the basis of analysis of distribution characteristics of methane, C1/(C2+C3) and characteristics of hydrocarbon isotopic compositions, the authors analyzed the cause of gas hydrate and the geochemical significance of acidolysis hydrocarbon isotopic compositions. Combined geochemical data with geological data, the best block for gas hydrate bearing was selected and the occurrence of gas hydrate in the working area was prospected.