The Middle-Lower Yangtze River valley is one of the most important Cu-Fe polymetallic belts in China, in which hosts many volcanic basins, such as Li-Shu, Li-Yang, Ning-Wu, Fan-Chang, Lu-Zong, Huai-Ning and Jin-Niu volcanic basin. Based on the contributions of the previous researchers as well as the fundamental studies in recent years mainly on Luzong Basin and Ningwu Basin, this paper discussed the geological characteristics, the temporal-spatial framework, and geochemistry, geochronology of petrogenesis and mineralization and metallogenetic model of the volcanic basins in the Middle-Lower Yangtze metallogenetic belt. The chronological results of the igneous rocks suggest that the magmatic rocks in the volcanic basins formed in Early Cretaceous (135~123 Ma). This paper proposes a petrogenetic and metallogenetic model for the volcanic basins in the Middle and