According to laboratory model tests on anti-slide pile’s durability, a new time-varying model simulating concrete neutralization of pile body affected by acid-stress coupling is proposed. Taking concrete strength grade, construction quality, rising and drawdown of reservoir water level, admixture and mineral admixture into account, the author established a prediction model of concrete neutralization depth. By applying the theory of neutralization remains, the author proposed a method to predict anti-slide pile’s durability lifespan in reservoir area based on the concrete neutralization and reinforcement corrosion.