The Karamaili ductile-brittle shear structural beh was formed in the middle-late Variscan time, which can be divided into two different tec- tonic deformation periods the collision extrusion period and post-collision strike-slip extension period, corresponding to four major evolutionary stages of thrust nappe, left-lateral strike-slip, right-lateral strike-slip and extension. Gold mineralization occurred in thrust nappe type ductile shear zone of the col- lision period, and metallogenesis occurred in the late post-collision period, C2-P(290 ~ 260Ma) , belonging to right-lateral strike-slip and extensional de- formation stage. The tectonic deformation control on gold mineralization in space is expressed by geological discontinuity between the ductile-brittle and brittle deformation in the shallow subsurface and ductile deformation at depth. The gold mineralization kept up with the ductile-brittle and brittle deforma- tion and had a significant superposition relationship with the ductile deformation. Ductile-brittle and brittle structure controlled ore body unified in the right-lateral strike-slip shear and extensional system, with different deformation levels, deformation characteristics and mineralization characteristics. Su- perposition relationships between tectonic deformation and gold mineralization in space have two mineralization time response and multi-stage metallogenic records, which showed superimposed and complex mineralization in time successively, spatial superposition and material various sources. The compres- sion-extension conversion process of regional tectonic background was the formation mechanism of ductile-brittle deformation conversion and gold minerali- zation. Geodynamic background of mineralization contains thrust-nappe type ductile deformation in the collision orogenic stage, right-lateral strike-slip type ductile-brittle deformation and gold initial mineralization in collision orogenic compression-extension conversion s~age, brittle deformation and main gold mineralization in extension orogenic stage. The study on the relationship between gold mineralization, time, and material around geological bodies indi- cates that the gold mineralization was jointly controlled by source beds of volcanic host rocks, tectonic deformation evolution and alkaline granitic intrusion activities in the late Variscan time.