Quantitative paleobiology is a well established field of paleobiology. The purpose of this paper is to describe some quantitative methods that can be applied in the morphometric study of Precambrian organisms. The phylogenetic affinity of many Precambrian fossils remains obscure, and their morphological features are more objectively described by a series of presence/absence (1/0) characters, rather than multivariate continuous measurements. Widely used methods in testing sampling bias and estimating confidence intervals include rarefaction, randomization, and bootstrapping. The authors use three case studies-morphological evolution of the Ediacara biota, Proterozoic macroalgae, and Proterozoic-Cambrian acritarchs.