The low permeability oil and gas resources include tight sandstone gas reservoirs and low permeability reservoirs, which have an important practical significance to increase the reserve and production in the current oil and gas exploration. Oil and gas geochemical exploration has the same exploration concept with the current dynamic oil and gas resource exploration, and has an advantage in low permeability oil and gas resources exploration. It plays an important role for geochemical exploration technology in the low permeability oil and gas resources exploration based on the two regional geochemical explorations.