Using airborne hyperspectral remote sensing (CASI/SASI) data, the abnormal information of the altered minerals of the Jintanzi-mingjingou area of the Beishan metallogenic belt in Gansu was extracted and analyzed. The distribution and formation of altered minerals were summarized. Combined with the typical rock and mineral results by ASD ground spectral measurements, we analyzed the spectral curve characteristics of different geological alteration minerals. On the basis of comprehensive analyzing of metallogenic geological conditions of gold deposits in the Beishan minerogenetie belt, geological sections for altered minerals were carried out using spectral measurements. Prospecting models by hyperspectral remote sensing were established on the basis of the gold deposits in this region. According to the geological background and geochemical anomaly characteristics, the application of hyperspectral anomaly in metallogenic prediction was discussed. The geological information showed that the targeted hyperspectral anomaly regions are potential for Au mineralization, which can be concluded that hyperspectral remote sensing can provide precise and reliable information for mineral exploration.