Quantitative studies on the Paleogene sedimentary filling history and analysis of its controlling factors were carried out in Qaidam Basin. Western region of Qaidam Basin can be divided into several secondary uplifts and depressions controlled by Cenozoic strike-slip process of Altyn Tagh. It can be divided into two types of sedimentary areas during Xiagancaigou deposition period bounded by Jianding Mountains-Nanyi Mountains-Youquanzi: 1) proximal deposits of alluvial fan-fan delta-sub-lacustrine fan-semi-deep lake depositional systems at the front zone of Arkin Mountains; and 2) alluvial fan-fluvial-delta-shore-shallow lacustrine depositional systems at Jiandingshan-Dafengshan ramp zone.