There is no indicator to directly determine the shearing sense of the strike-slip fault in seismic profiles until the model presented in this paper. The authors present a concept model to directly determine the shearing sense of strike-slip faults in seismic profiles. On the assumption of that the thickness of certain strata is thinning in a direction and thickening in the opposite direction monotonously, the strata thicknesses of both walls of a fault, the strike of which parallel or oblique to the strata thickness changing direction, must be different. If the thicknesses of both fault walls are measured, the shearing sense of the fault would be uniquely determined. The fault wall with the thinner thickness of the certain strata must slip from the thinning direction of the strata.