This paper provides the zircon LA-ICP-MS U-Pb isotopic dating result of the amphibolite from Altyn Tagh Group in the southern margin of Altyn Tagh and discusses its geological significance. The new data of isotopic chronology indicated that there existed a tectothermal event which corresponds to Lüliang orogenic movement in China and maybe related to the converging or breakup event of global Columbia suppercontinent in Paleoproterozoic. The result also indicate that there are Neoarchean-Paleoproterozoic metamorphosed basement in the Altyn Tagh area and provide a new data for research Precambrian teotothermal events and the evolution of Altyn Tagh belt.