Yiliang-Zhenxiong Pb-Zn metallogenic district is located in Sichuan-Yunnan-Guizhou lead-zinc metallogenic Province. There has been 89 proven deposits and ore points in this district, with proven resources being 68.9 million tons. By using statistical data of unit amount of information, establish fitting function, and determine parameters of function, this paper provided the quantitative estimation of resource prediction, showing good potential prospecting.