The Middle-Lower Yangtze metallogenic belt is an intra-continental belt dominated by Yanshanian magmatic mineralization. Based on the investigation of regional metallogenic background, the iron ore types are subdivided. It pointed out that some problems which affect iron deposit prospecting need to solve. According to the progress in deep-iron deposit prospecting, the focus of this study is to discuss similarities and differences of the iron mineralization in the Ningwu and Luzong volcanic-sedimentary basins, and some issues related to deep-iron ore prospecting. It is suggested that the deep-iron prospecting in this area should concentrate on the floor of the sedimentary basin and transitional zone of the basin and uplift areas.