The Zhouzhuang Ag-Pb-Zn ore deposit was recently discovered in the southwestern Henan Province where there are some other Ag-Pb-Zn ore deposits. It occurred in an inter-plate tectonic-magmatic geological environment after Indosinian orogeny. The ore-body is mainly in the Erlangping Group and the veins of quartz-(Ag-Pb-Zn) sulfides filled in the fault fractures whose strike-directions are perpendicular to the orogenic belt. The ore-forming fluid was mainly from the magma or the metamorphic water, and mixed by some meteoric water in the late stage. This study gives some new information for understanding the metallogeny of Ag-Pb-Zn in southwestern Henan Province.