lang=EN-US>The extensive granulite inclusions in alkaline intrusive rocks are considered as materials of lower curst in the region of western Yunnan. In order to reveal the Pb isotopic composition of lower crust in this region, the authors systematically collected samples of the granulite inclusions in alkaline intrusive rocks and selected the plagioclase and garnet et al. from them. Then the Pb isotopic composition of these minerals was determined. Based on the Pb isotopic composition of upper crust and mantle having been determined, the authors build the Pb isotopic composition of three-dimensional lithosphere in the region oflang=EN-US> western Yunnan. And by comparing the Pb isotopic composition of Jinding Pb-Zn deposit, the authors discovered that Pb in the Jinding Pb-Zn deposit is not the upper mantle Pb; it may be derived from the lower crust and sedimentary rocks in the Lanping Basin.