Based on the latest data from wells and seismic interpretation, this paper firstly discussed the Cenozoic fault geometry and evolu- tion of the eastern part of southern Altun slope in Qaidam basin. According to the planar distribution, the fault can be divided into three groups with NW, NEE and NWW strikes. And on the basis of the profile evolution, there are obviously three stages in the development of Cenozoic fault: in the Paleocene to Eocene, the north tilted fault with the strike of NWW in Jiandingshan area was formed, and the NW- trending fault in Dongping-Niubiziliang-Eboliang nose-like structural belt was positively inversed as well; in the Miocene, NE-trending faults appeared, and in the Pliocene, the south tilted compresso-shear faults with the strike of NWW came into being. Also, by means of for- mation restoration and structural balance, combined with the principle of material mechanics, the orientations of maximum principal stress in each geological time were determined. Finally, according to the relationship between the orientation of maximum principal compressive stress and the fault activity, the fault close and open processes were discussed, and it is suggested from regional hydrocarbon generation and expulsion history that the Cenozoic fault takes an important part in the large-scale gas accumulation in this piedmont slope bell.