The Mohailaheng and Dongmozhazhua Pb-Zn deposits in the Yushu area of Qinghai Province, are the two typical Pb-Zn deposits in the Cu-Pb-Zn polymetallic mineralization belt for the northern part of the Nujiang-Lancangjiang-Jinshajiang area. The authors thought the sources of ore-forming material were derived from the sedimentary strata by the research of sulfur, lead, strontium and neodymium isotope compositions of the Dongmozhazhua lead-zinc ore deposit. On the basis of geological field observations, the authors also made the research on the Mohailaheng lead-zinc ore deposit and selected sulfide minerals and barite for S isotope compositions analyses, sulfide minerals, gangue minerals and regional strata for Pb isotope compositions analyses, and gangue minerals for Sr-Nd isotope compositions.δ34S values of sulfide minerals are -30.0‰~+7.4‰, and show peaks at -18‰~-2‰, reflecting the characteristic of light sulfur.