In this paper, the authors discuss the relationship between mankind settlement sites and 6 topography factors in Wuding River Basin of Shaanxi in China during the Longshan period. This study aims to establish the digital elevation model of Wuding River Basin by GIS software. The main method of this study is to overlay the distribution of 293 Longshan sites with spatial analysis results of the digital elevation model, and to execute cluster analysis by SPSS software. The result shows that settlement behavior has a strong relationship with the hydrological condition, landform and ground slope, but no obvious relationship with the slope direction. The priority order of topography factors which affected the mankind settlement is that landform types, the distance to the river, the ground slope, the river grade and the slope direction.