The Laojinyan Pb-Zn deposit is a large one in the Ebian-Mabian metallogenic belt. The host rock is dark grey impure dolomitite of the Dengying Formation which is controlled by Nearly N-S-trending Ebian-Leipo fracture zone and NE-trending Hanyuan-Emei depression. This paper deals with ore genesis, ore guides and prospecting perspective based on regional geological setting, ore-forming geological conditions and principal ore control factors for the Laojinyan Pb-Zn deposit.