Free surface related multiple elimination is very difficult for ocean bottom seismometer (OBS) data processing and imaging. The multiples of OBS data have the characteristics of strong energy and long period, which seriously impact the processing and imaging of primaries. The interval of OBS stations usually is large, which is different from conventional streamer acquisition. Therefore, the conventional wave-equation-based method of free surface related multiple elimination cannot deal with the sparse OBS data. In this paper, we introduce estimation of primaries and multiples by sparse inversion (EPSI) to OBS multiples elimination with integration of streamer data. We first analyse the mechanism of multiples, and then give the methodology of OBS multiples elimination using EPSI with integration of streamer data. By using the information of streamer data, we achieve the multiples elimination of sparse OBS data. EPSI directly estimates primaries using sparse inversion, and avoids adaptive subtraction in surfacerelated multiple elimination (SRME) method. Therefore, EPSI can preserve the primaries. Synthetic data example demonstrates that the proposed method can effectively primaries of OBS data. effective estimate.