The Tongkeng-Changpo cassiterite sulfde deposit is the largest and most representative deposit in the Dachang orefield, Guangxi Province. This paper made a systematic analysis on characteristics of ore lead isotopes from this deposit and studies the source of mineralization materials of the de- posit coupled using the whole-orientation comparison method and △β-△γ trace method. The result indicates that the ore-forming materials are mainly from magma rocks, Devonian strata and the basement, and partly from mantle. Mineralization process of the deposit has undergone two periods, i. e. , the early mineralization stage related to basic magmatic activity (mantle source), and the later stage related to acidic magmatic activity (mixing source).