Namucuo-Jiali fractural zone is part of Shiquanhe-Shenzha-Jiali tectonic belt and controls rock distribution and boundaries of major geological bodies. On either sides of the zone occur various geochemical anomalies and large-medium-sized ore deposits and occurrences. Based on analysis of geological, geophysical, geochemical and remote sensing data and relation of the known ore deposits to stratigraphy, tectonics and magmatic rocks and characteristics of Cu-Pb-Zn polymetallic mineralization and distribution pattern along the zone, the ore prospecting model is established.