Slope disintegration is a special type of water and soil loss phenomenon in the south of China. Based on particle flow theory and finite volume method of fluid dynamics, the Meso-mechanieal parameters obtained by com- paring the PFC3~ and that of triaxiaI test results, a numerical model of slope disintegration is set up. The gradual forming process of slope disintegration is simulated under different rain intensity. The results show the failure under- goes a process of fissure formed and developed until slope disintegration occurs. Under high rain intensity, it has the features of blocks and multi-grades. Meanwhile, the development of the permeability, pore pressure and seep- age discharge in the slope are also discussed. Permeability increases with time passing until it arrives its maximum, then decreases; While the seepage discharge keeps increasing, especially sharply under heavy rain; The pore pres- sure under low rain intensity firstly increases, then is steady, hut fluctuates under high rain intensity. The results of the research is similar to the site conditions, which proves the feasibility of particle flow theory in the study of mechanism of slope disintegration.