Cosmogenic dating (in situ cosmogenic nuclides) has been widely used in geologic and geographic domain. There are a lot of materials which can be used in cosmogenic dating method. Because of its tight crystal structure, quartz can minimize possible contamination by meteoric UP>10Be, and also for its low ²⁷Al content, it becomes an ideal material for cosmogenic dating method. During the process of the isolation of ¹⁰Be and ²⁶Al from quartz sample, quartz isolation and purification are one of the key steps. HCl/H₂O₂ and HF/HNO₃ leaching is a safe method used to isolate and purify the quartz samples widely. The results of experiment reveal that the purification efficiency can be enhanced by increasing the leaching solution concentration and the amount of sample, and ultrasonic cleaner can be replaced by hotplate /magnetic stirrer.