It is generally considered Ordovician break-slope of Tarim Basin with advantage of hydrocarbon accumulation, may directly dominate the distribution of reservoirs after the exploration breakthrough of discovery of Tazhong Ⅰ break-slope. Therefore, the authors have a series of studies aiming at break-slope. Analyses of characteristics of hydrocarbons and inclusions from wells in Gucheng and Luoxi areas suggest that the original reservoirs in Tadong break-slope have been damaged and the type of late filling hydrocarbons is obvious different from that of original. The divergences of hydrocarbon accumulations in Gucheng and Luoxi are mainly caused by the differences of source kitchen thermal history, structural and fault evolutions of two areas. And the north part of Gucheng break slope zone and the plateau frontier slope of the west part of Luoxi break slope zone are possibly beneficial oil and gas exploration orientation.