The Nanyili granite pluton is located in Bikou block on the northwestern margin of the Yangtze Plate. This paper reports the geochemistry of the Nanyili granite and discusses its genesis, ore-forming material source and geological significance. The results show that the Nanyili granite pluton was formed in a typical post-collsional tectonic environment. It is probable that the collision between the North China and Yangtze plates during the Triassic resulted in obvious thickening of the crust. Under the extension and thinning tectonic mechanism, the metabasaltic and metapelitic rocks of the crust were partially melted through the amphibolitic dehydration.