The study of sequence stratigraphy is carried out in central Huanghua Depression using 3D seismic data, drilling, and well logging data. The Paleogene of the studied area can be divided into three second-order sequences, and 11 third-order sequences. Two kinds of structural slope-break are developed in the Qibei slope: faulted slope-break and flexural slope-break. The development and evolution of the slope-breaks are episodic and successive: in early period, it is faulted slope-break; in later period, it is flexural slope-break. Different kinds of slope-breaks have different sequence stratigraphic patterns and inner systems tracts. The faulted slope-breaks control the development of lowstand fan delta sandbodies and combination structural-lithologic traps. The surrounding areas of the slope-breaks are favorable for the development of non-structural traps, and have great potential for exploration.