This paper discusses Permian tectonic setting of North Qiangtang-Qamdo Block in some aspects. Studies of fusulinids, corals and brachiopods assemblages have indicated that the Permian faunas in southern Qinghai Province have always been the warm Tethyan type which shows more similarity with Tethyan and the features of the Yangtzephile plate. The geochemical features of the cherts from the northern border of North Qiangtang-Qamdo Block reveal that North Qiangtang-Qamdo basin probably had a continental crust structure. The geochemical features of the Permian sandstones and siltstones suggest that the basin should be a continental crust rift basin formed within extensional setting during Early and Middle Permian, and tectonic setting of provenances was of the island arc type in Late Permian.