On the basis of field outcrop, seismic and well data, Permian-Triassic strata erosion thickness of Hami Depression can be calculated by means of balanced section, seismic stratigraphy, horizon comparison, proximity thickness ratio and deposition rate. Accordingly, the Permian-Triassic original formation thickness can be recovered. Consequently the Permian- Triassic prototype basin of Hami Depression can be recovered and its depocenter evolution is also discussed in the paper.