The authors investigated the spatial and temporal variations of b-values before nineteen earthquakes with M≥6.5 in the Sichuan-Yunnan region from 1951 to 2005 using regional small earthquake data. The results show that spatial b-value variations portending M≥6.5 earthquakes in the Sichuan-Yunnan region are insignificant. Less than 50% of the major earthquakes occurred in the regions with low b-values relative to the entire study area. In terms of temporal evolutions,the b-values in seismic source regions showed a systematic drop before the occurrence of earthquake. They showed an obvious decreasing trend during the period one year prior to strong earthquakes in 58% of the seismic source regions. Combined with other geological and seismological data,the short-term seismicity data can provide certain enlightenment for the estimation of potential seismic hazard in specific regions.