Taking into account various factors that may influence the groundwater specific vulnerability, including topography, strata, hydrogeology and human activities, this paper selected 9 indices from these factors, and constructed nonlinear fuzzy membership with method of fuzzy comprehensive evaluation. The membership degrees of these indices were calculated, and then the groundwater specific vulnerability in Guangzhou was assessed combining with the GIS technology of spatial analysis. The results indicate that the indices of special vulnerability change in the range of 2.99~22.16, and could be divided into 5 grades. It comes to the conclusion that the groundwater in Guangzhou is easily polluted, and there are much obvious regional differences.