Panzhihua-Xichang area, located in the southwest margin of the Yangtze platform, experienced several stages tectonic-magmatic activities and metamorphism and are the important Cu-Ni-PGE geochemical province in China with good Cu-Ni-PGE ore-forming geological condition. Recently, with the rapid development of the mining industry and the consumption of the mineral resources, new metallogenic-prospecting theory and methods used in exploration are the key factors for finding out deposits in this area. Supported by the MAPGIS and using Weights of Evidence Method, the authors predict the targets of exploration programs of the Cu-Ni-PGE ores with good results and screen several important prospecting target areas such as Miesiluo area.