Paleo-uplift tectonic evolution impacted on hydrocarbon generation, migration and accumulation in the basin. Tectonic characteristics and inversion history of Kartake uplift in central Tarim Basin were researched. The results show that Kartake uplift displayed more performances for the basement-involved fracture, a number of “Y”-shaped fractures, flower-shaped structure pattern, and the majority of fractures broken down to Permian top. From Sinian to Early Ordovician, Kartake uplift was a northward slope, then at the end of Middle Ordovician, the aforementioned fracture tectonic style formed and the embryonic shape of Kartake uplift basically formed because the stress in the Tarim Basin changed from tension to compression and fractures was inversed. From Late Ordovician to the end of Middle Devonian, uplift shape was set basically, and structural feature was remained so far. Although from Middle Devonian to Miocene was a strong tectonic movement phase, the form of Katake uplift didn’t change.