The Duocaima ore deposit is a newly-found large Pb-Zn deposit in Tuotuohe area, Qinghai Province. Studies of mineral prospect evaluation, ore controls, and localization-prognosis were carried out to solve the key problems in the process of mineral exploration. The authors summarize the present and the previous studies and propose a mineral prospecting approach (integrated geological, geochemical, geophysical, and remote-sensing methods) for exploiting Duocaima-like Pb-Zn deposits.