The characteristics of formation of Jilin Zhengcha Pb-Zn deposit is of polygene, multistage and multiphase and related to Yanshan porphyry. After research on geological features, isotope geochemistry features and metallogenic mechanism, the writer believes that metallogenic substance has double sources-strata and magma. Metallogenic water is the mixture of magma and precipitate water. Metallogenic heat is from magmatism of granoporphyre; the ore deposit belongs to stratabound skarn ore deposit.