Field survey shows that the macro-epicenter of October 6, 2008 Ms 6.6 Damxung earthquake is located at northern Yangyi graben in the north section of the Yadong-Gulu rift. The maximum intensity of the Damxung earthquake is Ⅸ degree and lies at Yangyi village (29°43. 3’N, 90°23. 6’E). The main boundary normal fault of Yangyi graben is NNE-trending, dipping to east and located at west side of Yangyi basin. It is main seismogenic tectonics on the Damxung earthquake that controls the site of macroepicenter, pattern of the iso-seismal contours, distribution of meizoseismal region and aftershocks. The field observation and focal mechanism solutions from HRV and NEIC indicate that the Damxung earthquake of October 6, 2008 occurred as a result of normal faulting along the western boundary fault of Yangyi graben.