The influence of tectonic movements, sea level changes and sediments supply on the development of the sequences in the Pearl River Mouth Basin are discussed in this paper. The result indicates that there were 3 important tectonic movements since Neogene. They produced the whole uplift or regional uplift of the basin to form unconformity surfaces and controlled the development of the 2nd order sequences. The sea-level fluctuations dominated the models of the 3rd order sequences. Tectonic movement, sea level change and sediments supply affected the development of the sequences in different orders, as a result, various sequence patterns formed in the study area.