In order to examine the influence of water-soil interactions on coefficient of permeability of soil, soil samples have been tested in laboratory with different chemical solutions. The results indicate that the coefficient of permeability are changed, and there exist both positive and negative effects on the specimens in this test.The SEM photos show that dissolution and deposition of water on soil composition and ion-exchange adsorption of water with soil can affect the soil microstructure and pore characteristics, and change the permeability of soil.