Based on the dislocation theory model, genetic algorithm was used to inverse the three-dimensional slip parameter of fault. The results showed that the inversion, which accorded with the geological result, was low on the whole, strike-slip component ︱U1︱<3.2 mm/a, dip-slip component ︱U2︱<1.54 mm/a, stretch component ︱U3︱<2.5 mm/a; low slip rate indicated the closure of the fault, the accumulation of stress and the probability of megaseism; part component, which was lager than the geological result, indicated that the actual GPS data inversion displayed the real-time active state of the fault; the results were stable because of the global convergence and independent initial value of genetic algorithm; stretch component indicated that the part was irregular and the space activities of different sub-faults were inhomogeneous.