In Qimantage area of the East Kunlun region, Xinjiang many ore deposits (occurrences) which are dominated by Fe, Pb, Zn, Cu, Au, W, and Sn repectively have been discovered. According to region- al geological and metallogical condition, regional geochemical characteristics of Weibao area and Pb-Zn ore-hosted strata and occurrence and mineralization characteristics, wall rock alteration and ore material source of the Pb-Zn deposits in Weibao area the area possesses geological and geochemical conditions by which large Pb-Zn deposits could be formed thus is potential for further exploration of the deposits. Pros- pecting marks are summarized and empirical prospecting model is built. Pb-zn ore prospecting orientations are pointed out and prospecting targets located and suggestions for exploration of different deposits put forward.