In order to determine the petrogenetic and metallogentic ages of the deposit, the authors emphatically studied zircon LA-ICP-MS and molybdenite Re-Os chronology of the granite. Combined with the precise chronological data, this paper discusses in detail the geodynamic setting of the deposit. Combined with ore deposit geology and mineralization epoch as well as regional tectonic evolution, the authors have reached the conclusion that the formation of the Huanggangliang Fe-Sn deposit in the Great Hinggan region occurred at the peak metallogenic stage of 140 Ma. The tectonic setting of the deposit was in the transition period from lithosphere compression to extension.