The tectonic geochemistry characteristics of Sinongduo lead-zinc mining area in the Xietongmen country, Tibet have been systematically summarized through the geological mapping and tectonic geochemistry survey in a scale of 1:10000 in this paper. Both concentration clarke and variation coefficient of Ag, Pb, As, Sb, Bi in different lithology are high, which indicates that these elements have been involved in mineralization. The factor analysis shows the mineralization has multi-stages. The main metallogenic elements association is Pb, Zn, Mn which can be used as the indicator elements for prospecting. Four tectonic geochemistry anomaly belt have been delineated based on the geological and geochemical analysis, and among them Ⅰand Ⅱ anomaly belt have the better prospecting potential.