The analysis of wave impedance difference and forward modeling reveals that the impedance of oil reservoir after flooded by water increase 30% in Gaoliu block, much higher than 4% calculated by empirical method. According to the forward modeling research, the amplitude difference between oil layer and water layer is 4 ~ 5 times higher than the wall rock which has no amplitude difference (equivalent to noise).Therefore, the 4D seismic technology is feasible in Gaoliu block for the geology condition, reservoir condition and seismic acquisition condition which can meet the key demand for 4D seismic research.