Based on detailed studies on deposit geology and mineral paragenetic stages of the Jiapigou gold belt, 20 samples formed at different ore stages were systematically collected from six gold mines with varying distances of 100 - 3622m from the Iiapigou fault zone for hydrogen and oxygen isotopic analyses. The Beigou mine, about 100 - 172m away from the fault zone, shows 8D values of -97‰ - -90‰ and BTM Ow values varying from -3.26‰ to 5. 49‰; located about 820 -830m away from the fault zone, the Erdaogou mine yields isotopic values of -95‰ - -94‰ for hydrogen and -4.58‰ - -0. 50‰ for oxygen; the hydrogen isotopes are -97‰ - -91‰ and oxygen isotopes are -3.58‰ - - 1.39‰ for the Sandaocha mine with a distance of 1385 - 1412m away from the fault zone; the Sidaocha mine, 2776 N 2802m away from the fault zone, shows 8D values of -99‰ - -80‰ and 8TM Owvalues of 0. 75‰ - 4. 69‰; the isotope analyses for one sample from the Bajiazi mine (about 3400m away from the fault zone) yield 8D value of - 102‰ and 81SOw value of 0. 22‰; the Jiapigou mine (3595 -3622m away from the fault zone) exhibits 8D values of - 108‰ - -92‰ and t5ts OW values of 2. 91‰ N 5.39‰. At the early ore stage, this deposit belt displays a wide range of 8D values varying from -97‰ to -80‰ and a narrow range of positive δ18Ow values (3.99‰ -5.49‰), with W/R ratio of at 0. 1 ; the main ore stage is characterized by more negative 8D values ( - 108‰ - -90‰), widely varying δ18Ow values ( -3.26‰ - 4. 71‰) and high W/R ratios (0. 1 -0. 5) ; the late ore stage has a narrow range of δD values ( -97‰ - -91‰), negative but concentrated δ18Ow values ( -4. 58%0 - -2. 68%0) and low W/R ratios (0. 01 N0. 1 ). The ore fluids at the early ore stage are dominated by metamorphic fluids mixed with minor amounts of magmatic fluids, and are featured by small W/R ratios. During the main ore stage, the ore fluids are the mixture by metamorphic and atmospheric fluid with high W/R ratios. And the hydrogen and oxygen isotopes and W/R ratios behaved spatial heterogeneity with varying distance from the Jiapigou fault zone, which indicates the ore fluids were dominanted by channel flow. The oxygen isotope compositions became larger with distance away from the Jiapigou fault while the hydrogen isotope compositions and W/R ratio slowly decrease. Interestingly, the lower hydrogen isotope compositions and W/R ratios are related with the larger proven gold resources, maybe indicating that the effective pressure of metallogenie system controlled the variation of W/R ratios and gold precipitation. During the late ore stage, the W/R ratio is the smallest, which indicates considerable meteoric water was added and the fluid diffusive flow resulted in isotopic homogenization. Therefore, it is inferred that the overlapped positions for low oxygen isotopic values and high hydrogen isotopic values and W/R ratios are the most favorable places for gold deposition, and thus should be the priority for further exploration.