Mushan Mo deposit, a typical porphyry molybdenum deposit occurs in the northern margin of Dabie Mountain, is characterized by veinlet-disseminated mineralization and typical porphyry hydrothermal system alteration envelope centering the unmineralized quartz core formed by silicification early at the top of granitic porphyry. The coexistence of vapour-rich and halite-bearing three-phase inclusions indicates that the primitive magmatic fluid has experienced phase separation under low pressure. The results of homogenization temperatures of fluid inclusions show that the ore-forming element including Mo, Cu deposited by cooling of ore-forming hydrothermal system. It concluded that rock forming and Mo mineralization of Mushan Mo deposit are resulted from the thickened continental crust by partial melting during post-collision of Dabie Mountain, and it happened nearly 10 Ma earlier than granitic magmatism peak (~130 Ma) in early Cretaceous in Dabie region.