The authors explore an approach on large scale of regional ecological risk assessment, and implement the integrated assessment of oft-com:office:smarttags" />China, so as to provide scientific support for eco-system risk recognition and risk prevention. Select the 10 natural disasters as ecological risk sources, 22 species of the ecosystem as risk receptors and consider eco-environmental vulnerability. The result shows that the high, medium risk level of eco-system areas account for 45% of China’s territory. The environmental protection and risk prevention are very important and need to go a long way. It is imperative to establish adaptive disaster reduction and risk prevention mechanisms, make rational use and conservation for the forests, grassland, farmland, wetlands and other ecosystems.