The eastern Nanling region in China is a world famous tungsten-polymetallic ore concentrated area. Based on the latest achievement of tungsten-tin-polymetallic ore prospecting and the summary of geological and geochemical characteristics of tungsten-tin-polymetallic deposits in the eastern Nanling region, this paper proposed a metallogenic model of the tungsten-tin-polymetallic deposits in the eastern Nanling region and further ore-prospecting direction aimed at tungsten-molybdenum-polymetallic deposits genetically related to the Yanshanian composite granite plutons and strata-bound skarn tungsten-tin-polymetallic deposits controlled by middle-upper Devonian systems in the eastern Nanling area.